In response to the quake, The Red Cross has launched efforts in Japan. Visit Redcross.org or text REDCROSS to 90999 to donate $10 from your phone.
Save the Children is currently organizing efforts and donations to their Children's Emergency Fund will support their outreach.
The Japan Earthquake and Tsunami Relief Fund was launched at GlobalGiving.org to garner funds for relief organizations helping victims and has already raised thousands, particularly from concerned Twitter users around the world.
For any who have loved ones abroad, Google has stepped up to help. Along with a tsunami alert posted on their front page, they've launched the Person Finder to help connect people that may have been displaced due to the disaster.
Our thoughts go out to everyone affected by this disaster.